教育经历：

2014年毕业于中科院上海药物91直播下载 ，获药物化学博士学位

2006年毕业于郑州大学，获药学学生学位

工作经历：

2026.8-至今，上海科技大学生命科学与技术学院、91直播下载 ，研究员、助理教授（TENURE-TRACK）

2020.08-2026.791直播下载-91直播网 ，抗体设计学实验室，副研究员

2017.10-2020.791直播下载-91直播网 ，抗体设计学实验室，助理研究员

2014.8-2017.9 91直播下载-91直播网 ，抗体化学实验室，博士后

研究兴趣：

以核酸编码组合库技术(Phage display, mRNA display, DEL)为基础，深度融合合成化学与前沿生命科学方法，系统开展面向重大疾病相关靶标的治疗性生物大分子、环肽及小分子的高效筛选、靶标功能验证与候选药物开发。具体内容包括：

1.组合库技术(Phage display, mRNA display, DEL)开发

2.活细胞原位组合库筛选技术开发

3.硒药物化学生物学

代表性论文:（*第一作者，#通讯作者）

1. J. Li*, Y. Yao*, S. Zhang*, W. Wang, W. Bi, J. Lv, W. Hou^#, P. Ma^#, H. Xu^#, Splint RNA-mediated Single-stranded DNA-Encoded Library Construction and Label-free Live Cell Selection, Chem. 2026, 12, 102945.

2. W. Zhou*, Y. Wang*, S. Zhang*, C. Zhang*, J. Pang, S. Hou, J. Li, Y. Yao, A. Su^#, P. Ma^#, H. Xu^#, W. Hou^#, Highly Selective and AI-Predictable Se-N Exchange Chemistry Between Benzoselenazolones and Boronic Acids for Programmable, Parallel, and DNA-Encoded Library Synthesis, Chem. Sci. 2026, 17, 225-239.

3. W. Hou*^,#, X. Zhou*, Z. Yang*, H. Xia*, Y. Wang, K. Xu, S. Hou, S. Zhang, D. Cui, P. Ma, W. Zhou^#, H. Xu^#, Multicomponent Reaction Integrating Selenium(II)-Nitrogen Exchange (SeNEx) Chemistry and Copper-Catalyzed Azide-Alkyne Cycloaddition (CuAAC), Angew. Chem. Int. Ed. 2025, 64, e202500942.

4. W. Hou*, S. Zhang*, W. Yi^#, P. Ma^#, H. Xu^#, DNA-Compatible Chemistry for DNA-Encoded Libraries and Beyond, Trends Chem. 2025, 7, 771-786.

5. H. Li*, Y. Liu*, S. Zhang*, L. Ma, Z. Zeng, Z. Zhou, V. Gandon, H. Xu^#, W. Yi^#, S. Wang^#, Access to N-α-deuterated amino acids and DNA conjugates via Ca(II)-HFIP-mediated reductive deutero-amination of α-oxo-carbonyl compounds, Nat. Commun. 2025, 16, 1816.

6. W. Hou*^,#, Y. Zhang*, F. Huang*, W. Chen*, Y. Gu, Y. Wang, J. Pang, H. Dong, K. Pan, S. Zhang, P. Ma, H. Xu^#, Bioinspired Selenium‐Nitrogen Exchange (SeNEx) Click Chemistry Suitable for Nanomole‐Scale Medicinal Chemistry and Bioconjugation, Angew. Chem. Int. Ed. 2024, 63, e202318534.

7. P. Ma*, S. Zhang*, Q. Huang, Y. Gu, Z. Zhou, W. Hou^#, W. Yi^#, H. Xu^#, Evolution of chemistry and selection technology for DNA-encoded library, Acta Pharm. Sin. B. 2024, 14, 492–516.

8. S. Zhang*, H. Zhang*, X. Liu*, P. Qi, T. Tan, S. Wang, H. Gao, H. Xu^#, Z. Zhou^#, W. Yi^#, Mask and Release Strategy‐Enabled Diversity‐Oriented Synthesis for DNA‐Encoded Library, Adv. Sci. 2024, 11, 2307049.

9. Z. Zhou*, Y. Gu*, L. Wu*, Y. Wang*, H. Xu, L. Ma, Z. Zhang, J. Zhao, W. Zhang, W. Peng, G. Yang, X. Yu, H. Xu^#, W. Yi^#, Organo-Se BTSAs-enabled performance: From racemic and asymmetric synthesis to click chemistry application, Chem. 2023, 9, 3335–3346.

10. H. Xu*^,#, Y. Wang*, H. Dong, Y. Zhang, Y. Gu, S. Zhang, Y. Meng, J. Li, X. Shi, Q. Ji, L. Liu, P. Ma, F. Ma^#, G. Yang^#, W. Hou^#, Selenylation Chemistry Suitable for on‐Plate Parallel and On‐DNA Library Synthesis Enabling High‐Throughput Medicinal Chemistry, Angew. Chem. Int. Ed. 2022, 61, e202206516.

11. H. Xu*^,#, T. Tan*, Y. Zhang, Y. Wang, K. Pan, Y. Yao, S. Zhang, Y. Gu, W. Chen, J. Li, H. Dong, Y. Meng, P. Ma^#, W. Hou^#, G. Yang^#, Metal-Free and Open-Air Arylation Reactions of Diaryliodonium Salts for DNA-Encoded Library Synthesis, Adv. Sci. 2022, 9, 2202790.

12. S. Wang*, X. Shi*, J. Li*, Q. Huang, Q. Ji, Y. Yao, T. Wang, L. Liu, M. Ye, Y. Deng, P. Ma^#, H. Xu^#, G. Yang^#, A Small Molecule Selected from a DNA‐Encoded Library of Natural Products That Binds to TNF‐α and Attenuates Inflammation In Vivo, Adv. Sci. 2022, 9, 2201258.

13. F. Ma, J. Li, S. Zhang, Y. Gu, T. Tan, W. Chen, S. Wang, H. Xu^#, G. Yang^#, R.A. Lerner^#, Metal-Catalyzed One-Pot On-DNA Syntheses of Diarylmethane and Thioether Derivatives, ACS Catal. 2022, 12, 1639–1649.

14. W. Hou^#, H. Xu^#, Incorporating Selenium into Heterocycles and Natural Products─From Chemical Properties to Pharmacological Activities, J. Med. Chem. 2022, 65, 4436–4456.

15. W. Hou^#, H. Dong, X. Zhang^#, Y. Wang, L. Su, H. Xu^#, Selenium as an Emerging Versatile Player in Heterocycles and Natural Products Modification, Drug Discov. Today, 2022, 27, 2268-2277.

16. H. Gao*, S. Lin*, S. Zhang*, W. Chen, X. Liu, G. Yang, R.A. Lerner, H. Xu^#, Z. Zhou^#, W. Yi^#, gem‐Difluoromethylene Alkyne‐Enabled Diverse C−H Functionalization and Application to the on‐DNA Synthesis of Difluorinated Isocoumarins, Angew. Chem. Int. Ed. 2021, 60, 1959–1966.

17. Q. Zheng*, H. Xu*, H. Wang, W.H. Du, N. Wang, H. Xiong, Y. Gu, L. Noodleman, K.B. Sharpless^#, G. Yang^#, P. Wu^#, Sulfur [¹⁸F]Fluoride Exchange Click Chemistry Enabled Ultrafast Late-Stage Radiosynthesis, J. Am. Chem. Soc. 2021, 143, 3753–3763.

18. H. Xu*, Y. Gu*, S. Zhang, H. Xiong, F. Ma, F. Lu, Q. Ji, L. Liu, P. Ma, W. Hou^#, G. Yang^#, R.A. Lerner^#, A Chemistry for Incorporation of Selenium into DNA‐Encoded Libraries, Angew. Chem. Int. Ed. 2020, 59, 13273–13280.

19. H. Xu*, F. Ma*, N. Wang, W. Hou, H. Xiong, F. Lu, J. Li, S. Wang, P. Ma, G. Yang^#, R.A. Lerner^#, DNA‐Encoded Libraries: Aryl Fluorosulfonates as Versatile Electrophiles Enabling Facile On‐DNA Suzuki, Sonogashira, and Buchwald Reactions, Adv. Sci. 2019, 6, 1901551.

20. P. Ma*, H. Xu*, J. Li*, F. Lu, F. Ma, S. Wang, H. Xiong, W. Wang, D. Buratto, F. Zonta, N. Wang, K. Liu, T. Hua, Z. Liu, G. Yang^#, R.A. Lerner^#, Functionality independent DNA encoding of complex natural products, Angew. Chem. Int. Ed. 2019, 58, 9254-9261.